*5.1.2 Occludin and coronary vascular injury diseases*

Coronary endothelial barrier dysfunction is closely related to ischemic heart disease. Endothelial barrier integrity and function are regulated by a variety of transmembrane proteins, including claudin family proteins, occludin, VE-cadherin, etc. In recent years, basic research on occludin and coronary artery injury-related diseases has found that in mouse model of coronary artery sclerosis, the expression of occludin in arterial endothelial cells decreased, and the atherosclerotic plaque was expanded. Conversely, up-regulation of occludin expression in arterial endothelial cells can alleviate the occurrence and development of plaque [86]. In conclusion, abnormal expression of occludin in coronary endothelial cells is directly related to the occurrence and development of heart disease.
