**4. Diagnosis**

Cardiovascular disease (CVD) remains as the principal cause of morbidity and mortality worldwide [17]. During last century multiples, studies have been developed with the intention to identify the association between several lifestyle factors and the probability of suffering CVD [18]. Moreover, it is established the presence of cardiovascular risk factors (CVRF) in early childhood is a predictor of CVD in their lifetime [18, 19].

At the end of the last century, some equipments were created and able to identify the endothelium condition through non-invasive tools. Flow-mediated dilation (FMD) has become the most popular and widely used method for examining noninvasive peripheral artery endothelium-dependent dilation [20].
