**5. Conclusions**

Appendicitis is known as one of the most cause of emergency surgery. But beyond facts of its surgical emergency, basic pathophysiology of the appendicitis were not completely a surgical process. Manifestations and process of the inflammation of the appendicitis were also related to its vascularization and the stability of perfusion into the inflamed tissue. Factors contributing the quality of vascularization were considered to have a significant role in determining whether an appendicitis is a process of inflammation without or with complication, between non-surgical and surgical case. This fact may be guide further study physicians to differentiate indications of appendectomy and to be selectively careful and to reduce the number of negative appendectomies. Hance, current information and data were still provided by animal research model and laboratories studies, but rationally related to clinical manifests. However researches on the current topic with human sample of appendicitis is currently still conducted.
