*Endothelial Dysfunction in Appendicitis DOI: http://dx.doi.org/10.5772/intechopen.107480*

VEGF in conclusion, a histopathological examination of microvessel thickness is required to investigate the influences of FA and VEGF towards the pathological process of appendicitis among the pediatric population. Both FA and VEGF could be associated with disease progression where lower levels often indicated a more complicated case. A higher FA was associated with less provocative conditions with less inflammation and endothelial damage and a higher VEGF often suggested better prognosis as VEGF was used in angiogenesis etc. However, in both studies FA and VEGF were still limited of evidence as statistically significantly different towards controls in their use as a biomarker in the diagnosis complicated appendicitis were done in animals but human reaches are still conducted. However other factors regarding the endothelial functions in appendix are still limited to VEGF in current studies, other mechanism related to endothelin and the Fas-ligand were also in conduct for further evidence for the current update [26, 35].
