Preface

The endothelium is a thin layer of cells that lines the inside of the heart and blood vessels. It is a fundamental determinant of cardiovascular health and its pathophysiological role has recently come under intense scrutiny.

This book presents novel aspects of endothelial dysfunction and provides a clinical context for them. It describes the molecular biology and genetics of endothelial dysfunction with a focus on potential therapeutic targets. It also discusses novel pathways associated with endothelial dysfunction and provides a real-world clinical correlate to emphasize the importance of understanding and managing endothelial dysfunction.

> **Alaeddin Abukabda** Assistant Professor of Physiology, Lake Erie College of Osteopathic Medicine, Erie, USA

### **Christopher Fonner**

Associate Professor of Physiology, Lake Erie College of Osteopathic Medicine, Erie, USA

**1**

Section 1

Molecular Biology and

Genetics of Endothelial

Dysfunction
