*3.3.4 Gastric cancer*

GMAN, a long non-coding RNA, is upregulated in stomach cancer patients and is linked to overall survival and metastasis process. It inhibits the translation of ephrin-A1 mRNA by binding to GMAN-AS in a competitive manner [158]. Interferon regulatory factor-1 (IRF-1) suppresses gastric cancer spread by suppressing Wnt/−catenin signaling and downregulating the MIR17HG-miR-18a/miR-19a axis to inhibit gastric cancer lung metastasis [159].
