*Deciphering and Targeting Epigenetics in Cancer Metastasis DOI: http://dx.doi.org/10.5772/intechopen.106584*

and this kind of morphology boost both their ability to spread, enter, and colonic tumor vasculature [81, 82]. These findings show that tumor cells with an elongated morphology may need to change their shape to become more rounded in order to successfully intravasate and endure shear forces within blood arteries. It's tempting to think that higher cortical acto–myosin contraction, which promotes the rounded morphology, also allows the cortical cytoskeleton to withstand more mechanical stress. Tumor cells have been found to form part of blood vessel walls in other imaging studies. GFPlabeled tumor cells have been shown to constitute part of the lumen of blood arteries using in situ imaging [80]. This behavior is likely to be linked to tumor cells expressing genes that are normally restricted to endothelial cells. In many circumstances, entering the bloodstream could be as simple as separating tumor cells from the walls of blood vessels.
