Preface

Cancer mortality and morbidity are primarily brought on by metastasis. The ability of neoplastic cells to spread and colonize distant tissues is their most dangerous trait. Most malignancies are curable when they are detected early and have not spread beyond the original tissue. However, cancer is frequently incurable when tumor cells have created colonies elsewhere.

Thus, this book's content provides comprehensive information on cancer metastasis with reference to specific cancer cases. The first section covers the formation of metastatic cells through the perturbation of cell-cell and cell-matrix adhesion and through matrix degradation, as well as the sub-topics of motility, intravasation, extravasation, metastatic colonization and angiogenesis. The next section considers the molecular mechanism of metastasis, discussing stromal cells and extracellular vesicles, and epigenetics in cancer metastasis. Factors affecting the molecular basis of cancer metastasis are discussed. The third section covers the molecular mechanism of breast cancer metastasis, and the link between molecular mechanisms and novel therapeutic approaches in non-small cell lung cancer brain metastasis. The final section of the book reviews current palliative therapies for bone cancer metastasis.

> **Yusuf Tutar** Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Istanbul, Turkey
