**5. Conclusions**

Cancer metastasis is a common cause of death. The role of epigenetics in the etiology of metastases cannot be ignored. To overcome cancer and its metastasis, many methods and technologies are applied to developing new drugs. In parallel with the development of specific and potent small-molecule inhibitors, some novel and cutting-edge technologies like proteolysis-targeting chimeras (PROTACs), RNA interference (RNAi), clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-based genome editing, and artificial intelligence (AI)-based drug design, in chemical biology show huge potentials for cancer treatment, which allows to screening therapeutics targeting almost all kinds of molecules, like proteins and epigenetic regulators [173].
