*3.3.3 Colorectal cancer*

Colostrum basic protein (CBP), a histone acetyltransferase (HAT), mediates DOT1L K358 acetylation and has a positive correlation with colorectal cancer stages. DOT1L acetylation confers DOT1L stability by blocking RNF8 binding to the protein and subsequent proteasomal degradation, but it has no effect on the enzyme's activity. DOT1L can catalyze the H3K79 methylation of genes involved in epithelial-mesenchymal transition, such as SNAIL and ZEB1, once stabilized [156].
