**9. Conclusion**

Cancer metastasis is the leading cause of cancer morbidity and death. Stromal cells such as endothelial cells, cancer-associated fibroblasts and adipocytes are all involved in cancer development, progression, and metastasis by aiding the spread of cancer from the point of origin to a distant disconnected part of the body. In recent years, clinicians have focused on these stromal cells to provide clinical therapy to patients with cancer. However, this field is relatively new and further research into the roles of these cells in cancer metastasis and the molecular mechanisms should be explored. This will provide a molecular understanding of different types of cancer, and lead to the development of different therapies that will enhance patient survival.
