**6. Conclusion**

The application of multi-kinase and angiogenetic factor inhibitors in the treatment of radioiodine refractory and advanced thyroid cancer has enabled the successful management of the disease and has revolutionized the management of radioiodine refractory and advanced thyroid cancer. As the application of these multi-kinase and angiogenetic factor inhibitors is related with an increase in progression-free survival and disease stabilization, further research is needed to identify the mechanisms involved in the acquired resistance to these agents and the ways to manage this resistance. Mutational testing in thyroid cancer may contribute to the application of targeted treatment.
