**5.1 Epidemiological evidence of the antitumor activity of statins**

Epidemiological studies have shown that statins reduce cancer mortality [74]. There is also a positive correlation between statin use and a reduction in cancer incidence [60, 74, 78]. However, other authors have not found this connection between taking statins and cancer risk [74]. Nevertheless, these epidemiological studies have been criticized for having intrinsic limitations and a retrospective approach [74]. In addition, another criticism is that the studies have been designed to evaluate the reduction of cholesterol levels and not the role it plays in oncogenesis [60], including sarcomas. Besides, clinical studies of statins and their antitumor action are few, limited, and inconclusive [61]. In addition, there is a discrepancy between data from preclinical and epidemiology regarding the lack of response to combination therapy in clinical trials. Moreover, unfortunately, clinical trials with statins and sarcomas were not found.
