**2. Role of lipid metabolism in tumorigenesis**

Changes in cancer cell metabolism are essential in tumor behavior, but it is not known how they interrelate (**Figure 1**). The high proliferative capacity of tumor cells generates high metabolic demands [5]. Lipids are necessary for cell survival, proliferation, differentiation, motility, cell structure, and cell signaling [6, 7]. Cholesterol stands out in cancer progression because tumor cells require more cholesterol than normal cells to achieve various functions [4, 8–10]. To reach this, some tumors overexpress genes from the cholesterol biosynthetic pathway to accomplish this goal [11].
