**Acknowledgements**

The author would like to thank Angelika Eggert, Nicole Hübener, Katharina Pardon, and Beat W. Schäfer for their support. This work was supported by grants from the Berliner Krebsgesellschaft (RIFF201913), and KINDerLEBEN e.V. Berlin. It is part of the EpiCycle Consortium(01KC2012E), Funding Program of the Federal Ministry of Education and Research (BMBF), Germany.
