**Meet the editor**

Dr. Pedro M. Baptista, Pharm.D., Ph.D., is currently a researcher at the Wake Forest Institute for Regenerative Medicine in Winston-Salem, NC, USA. This is a world-renown institution in the field of tissue and organ engineering, and the first to accomplish a transplantation of an in vitro-grown organ, the bladder, into a human patient. Dr. Baptista is originally from Portugal,

where he obtained his Pharmacy degree at the School of Pharmacy of the University of Lisbon. He has worked in clinical research for the pharmaceutical industry before engaging in his doctoral dissertation project in liver bioengineering and regeneration. His doctoral work resulted in the development of the first human liver ever made in a laboratory, impacting the scientific community at large and widely broadcasted in the media all around the world. He has more than 20 scientific publications including a book, book chapters and several papers and reviews published in prestigious international journals. He is also a regular contributor to the portuguese pharmaceutical magazine "Pharmacy and Distribution" where he publishes a monthly chronicle. Dr. Baptista's current research interests focus on investigating methods to expand stem/progenitor cell numbers required for organ bioengineering and in making the long term transplantation of these lab-grown organs a reality.

Contents

**Preface IX** 

**Section 1 Cellular and Molecular** 

Chapter 1 **Hepatocytes and Progenitor –** 

**Mechanisms of Regeneration 1** 

Laura Amicone, Franca Citarella, Marco Tripodi and Carla Cicchini

Chapter 2 **Liver Progenitor Cells, Cancer Stem** 

Janina E.E. Tirnitz-Parker,

Chapter 3 **Hepatic Progenitors of the Liver** 

Chapter 5 **Matrix Restructuring During Liver** 

and Clara Zúñiga-Pérez

Haruko Ogawa, Kotone Sano,

Eva Schmelzer

Chapter 4 **Possible Roles of Nuclear** 

Chapter 6 **The Protective Effect of** 

**Stem Cells in Regeneration and Therapy 3** 

**Cells and Hepatocellular Carcinoma 17** 

George C.T. Yeoh and John K. Olynyk

**and Extra-Hepatic Tissues 43** 

**Lipids in Liver Regeneration 63**  M. Viola-Magni and P.B. Gahan

**Regeneration is Regulated by Glycosylation of the Matrix Glycoprotein Vitronectin 79** 

Naomi Sobukawa and Kimie Asanuma-Date

**Antioxidants in Alcohol Liver Damage 99**  José A. Morales González, Liliana Barajas-Esparza, Carmen Valadez-Vega, Eduardo Madrigal-Santillán, Jaime Esquivel-Soto, Cesar Esquivel-Chirino, Ana María Téllez-López, Maricela López-Orozco
