**6. Summary**

The aim of presented studies was to influence regeneration of liver parenchyma after portal vein embolization/ligation. Physiological solution (controls, 9 animals) or TNF-α (9) or interleukin-6 (8) or MSC (6) were applied into non-occluded portal vein branches after ligation of portal vein branches for right lobes. Administration of MAB TGF-β1 was performed 24 hours after ligation (7). Compensatory hypertrophy (FLRV) was followed-up in next 14 days by regular ultrasonography, serum level of biochemical parametres and by histological examinations. Application of IL-6 and TNF-α augments hypertrophy of FLRV on 7th postoperative day in comparison to control group. In case of application of MAB TGF-β1 we observed maximal increase of FLRV between 3rd and 7th days. Application of MSC augments hypetrophy of FLRV on 3rd day. The biochemical and histological examinations did not prove any differences among the groups. The use of TNF-α, IL-6, MAB TGF-β1, MSC could increase the process of liver regeneration after portal vein ligation.

**Keywords:** Liver surgery, Liver regeneration, Experimental study, Porcine model, Experimental model, Portal vein embolization, TNF-α, Interleukin-6, Mesenchymal stem cells, TGF-β1.
