**4. Conclusion**

This study proposes that alterations of glycosylation, especially decreased sialylation of vitronectin, modulate tissue remodeling processes in multiple steps, especially HSC spreading and survival. Our findings suggest that the removal of sialic acid from vitronectin suppressed activation of stellate cells, indicating the possibility of a new treatment for or method to prevent liver cirrhosis. This will open new windows to the paradigm of glycoregenerative medicine, which is based on the modulatory functions of glycans of ECM glycoproteins such as vitronectin.
