**8.2 Important criteria for detecting suspected TE cases in immunocompromised patients**

It has been extensively discussed above that immunocompromised patients are highly susceptible to TE, and serious pathology occurs in such cases. Here, we will focus on the steps to reveal a TE in these patients.


Finally, it is worth mentioning that CNSToxoIndex evaluates the local synthesis of anti-toxoplasmic IgG in the CNS and their diffusion from blood as a consequence of blood-brain barrier disruption, and it is also a potent approach of TE diagnostics in HIV-positive individuals [99].

If a definitive diagnosis is desired, an important step in immunocompromised patients, lesions revealed by imaging methods should also be confirmed by histopathological and molecular methods.
