**Abstract**

*Pseudomonas aeruginosa* is an opportunistic gram-negative bacterium, which associates with a wide range of diseases. This bacterial type is found commonly in the environment, such as soils and water. Also, it represents the main cause of hospitalacquired infections, which was associated with high rates of morbidity and mortality among aging and/or immunocompromised patients. *Ps. aeruginosa* contains virulence factors that made them able to transmit and also gave them the ability to resist many types of antibiotics. Therefore, it represents a major challenge for health workers. One of the main characterizations of *Pseudomonas aeruginosa* is antibiotic resistance; this is associated with many types of genes that are encoded for different antibiotic resistance mechanisms. The efflux pump is a very important mechanism of this bacteria. *Ps. aeruginosa* can cause a wide range of diseases, such as pneumonia, urinary tract infections, ear infections, folliculitis, puncture wounds, cystic fibrosis, burn infections, endocarditis, endophthalmitis, meningitis, and many others.

**Keywords:** *Ps. aeruginosa*, transmission dynamics, virulence genes, toxins production, antibiotic resistance
