**8. Conclusion**

The opportunistic pathogen *P. aeruginosa* has been widely studied as one of the microorganisms prioritized for research and development of new therapies to treat nosocomial infections, given its high capacity to generate resistance to currently available antibiotics, adapting easily to environmental conditions. Although, the identification of the gene that confers antibiotic resistance to *P. aeruginosa* has been a complex task. It is known that there is a genetic battery that is part of its resistome, composed of genes such as CARB-3, CARB-4, PSE-1 (CARB-2), PSE-4 (CARB-1), OXA-18, OXA-2, OXA-21, OXA-10 (PSE-2), GyrA, GyrB, OprM, OprJ, OprN, MexB, MexD, MexF, and MexY. Other less studied genes encoding methyltransferase enzymes are also part of the *P. aeruginosa* resistome. The research of the *P. aeruginosa* resistome, as well as its interactome, has advanced thanks to the development of new sequencing technologies, within which pangenomics analysis has opened a horizon to improve the understanding of the genetic mechanisms underlying antibiotic resistance. Through this analysis, it is possible to identify common and unique genes within different strains of *P. aeruginosa*. The study of the resistome is part of the pangenomics analysis. Nevertheless, a thorough understanding of the *P. aeruginosa* resistome, its interactome, and other mechanisms of antibiotic resistance remains a challenge for researchers and a key element to consider in public health issues.

### **Acknowledgements**

We thank the University of Antioquia for their financial support to the project CODI 2017-15753.
