*2.10.4 Anti-allergic activity of probiotics*

In the past, probiotics have increased awareness of its causes and preventive measures in protecting and managing allergy disorders. In-vitro studies of some probiotic products, such as *Lactobacillus plantarum* L67, have demonstrated that the manufacture of interleukin 12 and interferon g at your host can prevent allergic diseases (park 2016). *L. plantarum* 06CC2 substantially relieved allergy symptoms in another research and decreased total immunoglobulin E concentrations, ovalbumin E specific immunoglobulin and histamine in the ovalbumin-sensitive mouse sera. *L. plantarum* 06CC2 is reported to enhance the interferon-g and interleukin-4 secretions substantially in the cells of spleen in mice, which alleviate allergy symptoms [97]. Further investigation may be useful in assessing the anti-allergic activity and method of action of probiotics.
