*2.8.2.1 Bifidobacteria and colorectal cancer*

Several research have looked at Bifidobacterium's ability to prevent and/or treat colorectal cancer. The bulk of research use mouse models to reach their conclusions,


#### **Table 4.**

*Probiotic strains of infant formula [76].*

and the results imply that a combination of prebiotics and bifidobacterial may minimize the incidence of carcinogen-induced malignant cells in mice [77]. For example, it has been demonstrated that Bifidobacterium animalis has anti-mutagenic activity while growing in MRS broth, effectively counteracting the action of the carcinogen 2-amino-3-methylimidazo [4, 5-f] quinolone [78]. It has also been established in vivo and in vitro that a B. longum and a B. breve strain protect DNA from carcinogeninduced damage and suppress the genotoxic impact of two separate carcinogens when evaluated in a rat model [79].
