*2.8.2 Bb12* Bifidobacterium

Bb12 has been available on the market for over 25 years and is one of the best probiotic strains accessible for the most extensive research. It was administered to babies alone or with several different probiotic strains and has demonstrated its well-tolerated and beneficial effects [73]. The Bb12, combined with Streptococcus thermophilus Th4, has already proven that infants are well accepted in a formulation and have decreased the colic levels, irritability, and antibiotic needs for 6 months [74]. Bb12 is highly colonized because to its excellent adherence to human mucus [75]. The gut microbiome of preterm children has previously demonstrated a beneficial influence (**Table 4**) [70].
