**Abstract**

The human gastrointestinal tract harbors an extremely complex and dynamic microbial community, including archaea, bacteria, viruses and eukaryota. This gut microbiota usually works with the host to promote health but can sometimes initiate or promote disease. Dysbiosis relationship in gut health indicating the role gut microbiota in promoting the development and progression of brain health. The human gut microbiota is a complex and dynamics microbial community that plays an important role in protecting the host against pathogenic microbes, modulating immunity and regulating metabolic processes. The insights can be elucidated with help of latest omics technology and animal model studies.

**Keywords:** gut microbiota-brain axis, human health, animal models
