**1. Introduction**

The gut microbiome has been widely accepted to be one of the vital factors causing various disease in human. This area of research has become the niche for many scientists from various fields to explore. Most of the research works are focused on elucidating the influence of gut microbiota in the brain development [1]. Diet plays a crucial role in altering the gut microbiota and some studies focuses on understanding how diet alters gut microbiota and its effect on the development or prevention of metabolic, cardiovascular and brain diseases [2]. Animal studies have always been an important tool in the biomedical research. The interactions of the gut microbiotabrain axis have been studied using various animal models. However, most of the animal research has only able to reveal the fundamental theory such as the diversity of microbial community, the potential microbial pathways and the dysbiosis of the gut microbiota due to diet and drug [3]. The inability of translating many great findings into human system is withdrawal point of animal work [3]. Later, the advancement in the omics-technology has pave the way in the identification of metabolic pathways, microbial species, and metabolites that have strong association with the progression and cure of diseases. Here we have reviewed the interaction of the gut microbiota and

brain axis, the pathways, and how the gut wealth affect the human health. Researches on microbiome is translatable into treatments that is able to alter the gut microbiome which could transform the common diseases. This paper also reviewed how the animal research and the application of omics technologies has contribute towards inventions of therapies.
