**5. Conclusion**

Despite recent progress in reducing the incidence of MDR with the use of conventional drugs during chemotherapy, there is still an evident deficit in their therapeutic efficiency in inhibiting MDR. Therefore, drug resistance remains a global concern and a principal cause of cancer-related mortalities. The problem of MDR in microorganisms is one of the world's present-day challenges. However, an improved understanding of the signaling pathways involved in drug resistance would assist in paving way for more therapeutic interventions.

The application of natural products from plants is currently proving to be a viable option in targeting the various signaling pathways associated with MDR. Hence, a great deal of attention is being paid to plant-based products due to their non-toxic effects. This review demonstrated the inherent capacity of polyphenolic phytochemicals in citrus to target the various pathways utilized to perpetuate MDR and the mechanisms to circumvent it.
