**7. Food-drug interaction**

Grapefruit juice, for example, has an identical moniker in the context of high food-drug interaction by changing the normal working of the cytochrome oxidase mechanism. Grapefruit juice (GFJ) and HMG-CoA reductase inhibitors, sometimes referred to as statins, have the most well food-drug interaction. Grapefruit juice, when consumed in high quantities (32 oz. a day), can block the cytochrome P450 3A4 (CYP3A4) enzyme and raise serum levels of medications processed by this route, such as some statin medicines [92]. Many researchers have identified drug-GFJ interactions caused by suppression of CYP3A enzymes, a subclass of cytochrome oxidase enzyme system [93]. Furanocoumarins (in GFJ) specifically inhibit gastrointestinal CYP 3A4, increasing the oral bioavailability of medicines that are CYP 3A4 substrates, such as felodipine and cyclosporine, and eventually causing toxicity [94].

## **8. Future prospective**

Oral supplementation delivery is acknowledged as the easiest, most efficient, and least expensive method for a broad range of medicinal significance [95]. Because of their heavy proportion in *Citrus*, bioflavonoids, such as naringenin, hesperidin, naringin, and polymethoxyflavones (PMFs) have been intensively investigated and encapsulated, and have illustrated medicinal characteristics *in vitro* and *in vivo* studies. Oral ingestion using novel encapsulating techniques, such as emulsification, liposomal interactions, hydro-gelation, nanoparticles, and membranes revolutionized the nutrition delivery mechanism [96]. Modern encapsulation techniques are developed to conserve bioflavonoids while improving target dispersion for medicinal benefits. The rapidly expanding worldwide food encapsulation business has shown higher demand and public knowledge of health additives and preventative measures for numerous diseases [92]. New unique delivery techniques must be developed to expedite the simple availability of *Citrus* bioflavonoid for medicines. Future studies,

on the other hand, would need to blur the lines between the laboratory and the customer by boosting output and enhancing shelf life.
