**6.** *Citrus* **fruit toxicity and safety profile**

In animal toxicological testing, bioactive chemicals obtained from *Citrus* fruits demonstrated a high level of security. Hesperidin extracted from *C. Sinensis* dried peel revealed a modest reported adverse impact level of 1 g/kg, and a median fatal dosage of 4.83 g/kg, Sprague–Dawley rats were subjected to a 90 day subchronic and acute oral toxicity study [88]. This dose is substantially smaller than the flavonoids employed in animal research to offer the (10–200 mg/kg) same therapeutic effects, suggesting an excellent safety profile in the animals. Furthermore, additional *Citrus* flavonoids, such as tangeretin, nobiletin, and naringin, have demonstrated satisfactory effectiveness and safety [89, 90]. Limonene and other terpene-rich *Citrus* taste molecules, including oil, essential oil, peel extract, and whole fruit extract, are usually believed to be harmless [91].
