*2.1.1.3 Cholesterol-oxidase gene from streptomycete fungus*

A *cholesterol-oxidase* gene from a streptomycete fungus has also been engineered into tobacco that was highly toxic to larvae of the boll weevil (*Anthonomus grandis*) and retarded the growth of the tobacco budworm (*Heliothis virescens*) by damaging the membranes of the insect-midgut epithelium [21–23].
