**7. Future prospect**

Flavonoid-rich diets have been shown to delay the onset of dementia-related diseases and prevent age-related cognitive decline. Alterations in cerebral blood flow caused by flavonoids, progenitor cells, quantitative changes in brain stem cells and gray matter density, as well as electrophysiological anomalies, can all be examined utilizing imaging and spectroscopic tools such as NMR and MRI. All of

#### *Flavonoids: Recent Advances and Applications in Crop Breeding DOI: http://dx.doi.org/10.5772/intechopen.107565*

these initiatives will result in mechanism-based linkages between flavonoid medication and brain activities, as well as therapeutic dosage data. Flavonoids have been shown to concentrate in the brain and activate Akt-CREB and ERK-CREB mediated memory, making them interesting therapeutic candidates for memory enhancement. Flavonoid-loaded nanoparticles, liposomes, or other nanocarriers can pave the way for flavonoids in the future by increasing the half-life of flavonoids in organisms, drug delivery strategies boost their effects. Moreover, since flavonoids are naturally occurring dietary components, therapeutically effective amounts of flavonoids can have varying lethal effects on cancer cell lines as well as tissues due to cancer heterogeneity. Ototoxicity is a side effect of chemotherapeutic medicines that patients experience during chemotherapy. According to one study, epigallocatechin-3-gallate protects patients against ototoxicity, which can also pave the door for flavonoids to be utilized as additive treatments to reduce the side effects of chemotherapy drugs. It is predicted that addressing difficulties like as bioavailability and metabolism, building physiologically acceptable in vitro models, determining the effects of processing, standard measuring methodologies, and adequate clinical biomarkers will surely influence the future of flavonoid research [144–146].
