**4.1 Effects and influence of flavanol rich cocoa on cognitive performance**

The potential of flavonoids to alter signaling pathways enhancing neuronal function and brain connection appears to be one of the processes underlying the health benefits of frequent cocoa consumption [123].

### **4.2 Role for polyphenols in the prevention of degenerative diseases**

Flavonoids protect the brain cells in a multitude of ways, such as by strengthening the functional neurons or by promoting neuronal regeneration. After 6-hydroxydopamine lesioning, it has been found that the citrus flavanone tangeretin preserves nigro-striatal integrity and functioning in the context of Parkinson's disease [124].
