*Integrins in Ovarian Cancer: Survival Pathways, Malignant Ascites and Targeted Photochemistry DOI: http://dx.doi.org/10.5772/intechopen.106725*

in benign and grade I tumors. Confirming the role of integrins in ovarian cancer cell progression, decreased ascites-induced and basal proliferation were observed in OVHS1 and HEY cell lines incubated with α6 and β1 antibodies. Similarly, decreased ascites-induced invasiveness was reported in OVCA 433 and HEY cell lines incubated with α6, β1, and uPAR antibodies.

Overall, acellular factors, such as integrins, play critical roles in shaping the ascitic tumor microenvironment of ovarian cancer and contribute to tumor growth, invasion, and metastasis. Since aberrant integrin signaling can increase invasiveness, chemoresistance, and metastasis of cancer cells, understanding the role of ascites and integrin expression in ovarian cancer is crucial for the development of targeted therapies.
