**7. Prognostic and predictive value of HE4 in ovarian cancer**

Presently, there is no predictive biomarker for the success of chemotherapy. Studies show that HE4 and CA 125 values become negative after fourth cycle chemotherapy if there is a good response. Rise in HE4 is seen earlier than CA 125. Long term progression-free survival is associated with the serum levels of biomarker lower than the mean value in the affected population at the time of diagnosis and the development of negativity of the marker after third cycle of chemotherapy. Monitoring of HE4 and Ca125 during chemotherapy especially after third cycle is recommended for their prognostic values [55].
