*2.1.4 YAP/TAZ transcriptional regulators*

Yes-associated protein 1 (YAP) and Transcriptional coactivator with PDZ-binding motif (TAZ) are two transcriptional regulators that play an important role in mechanotransduction, i.e., converting external mechanical inputs to cellular responses [67]. YAP and TAZ (YAP/TAZ) are known as coactivators in the Hippo pathway, a signaling pathway that plays a role in homeostasis, organ size control, cell differentiation, and the progression of various types of human cancer, including ovarian cancer [68, 69]. Active YAP/TAZ translocates to the nucleus to interact with TEA domain family member (TEAD) transcription factors, where the YAP/TAZ-TEAD protein complex transcribes genes that control cell proliferation and apoptosis [70]. In addition to their role in the Hippo pathway, YAP/TAZ also interact with the Wnt pathway and mediate Wnt signaling [68, 71]. Research has shown that integrins and other components in adhesion complexes, including FAK and Src, can also activate YAP/ TAZ to maintain mechanotransduction [40, 72]. The overexpression and activation of YAP/TAZ have been shown to be correlated with poor prognosis in ovarian cancer [73–79]. Specifically, YAP was shown to play an important role in ovarian cancer tumorigenesis, cell proliferation, invasion, and resistance to therapy *in vitro* and *in vivo* [74, 76]. Expression and activation of YAP [76] and TAZ [79] were also associated
