**2.3 Malignant ascites in integrin-mediated invasiveness in ovarian cancer**

Malignant ascites, the abnormal accumulation of fluid containing malignant cells in the peritoneum [92, 93], is more frequently associated with advanced-stage ovarian cancer than any other peritoneal malignancy, and represents a barrier to treatment [94, 95]. As shown in **Figure 3**, there are a variety of cellular and acellular factors in malignant ascites that contribute to disease progression, immune evasion, and even chemoresistance in ovarian cancer [92, 96]. Acellular factors
