Preface

Glioblastoma multiforme (GBM) has a complex pathogenesis and mutates and alters several key cellular pathways involving cell proliferation, cell migration, and tumor vessel angiogenesis. GBM is known for its rapidly progressive nature. It is a debilitating disease associated with limited response to therapies, poor outcomes, and a very short median overall survival. The diagnosis and management of glioblastomas require multimodal strategies and a multidisciplinary approach. Treatment may involve surgical resection, radiation therapy, and chemotherapy. Significant advances have been made to understand the pathology of GBM, particularly molecular mechanisms and targets for immunotherapy. Recent advances in genetic testing have improved our understanding of the glioblastoma category of brain tumors and have helped us decide on management and follow-up strategies. This book discusses the management of glioblastoma, isocitrate dehydrogenases (IDH)-mutated gliomas, evolving molecular diagnosis strategies, management of lesions involving the corpus callosum, glycan and glycosylation as potential targets for designing therapies, systemic treatment in glioblastoma, the potential utility of lipid-based nano-drug carriers, the role of cancer stem cells and cardiac glycosides in disease evaluation and treatment, management of glioblastoma in the elderly, research related to immunization with autologous IFN-D, and the use of canine glioma as a model for human glioblastoma. This book is a useful resource for understanding and exploring current advances in GBM treatment, including the identification of the molecular characteristics that determine the malignant phenotype, which t may further help to develop effective management strategies including immunotherapy.

> **Amit Agrawal** Professor, Department of Neurosurgery, All India Institute of Medical Sciences, Bhopal, India

**Daulat Singh Kunwar** Department of Radiotherapy and Clinical Oncology, Government Doon Medical College, Dehradun, India

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Section 1

Glioblastoma
