**5. Conclusion**

Liver cancer comprises of different types depend upon their origin such as liver stem cells, hepatocytes, cholangiocytes, and hepatoblasts, the most common type is hepatocellular carcinoma (HCC) or primary liver cancer Worldwide, its prevalence is 75% of all types of liver cancers and every fifth male and seventh in female is diagnosed with liver cancer. The etiology is linked with activation of multiple processes of apoptotic response, dysregulation of cell cycle and the stimulation of signaling pathways that cause fibrogenic and inflammatory response. Currently, numerous therapeutic options are working to treat patients with HCC, the aim of all of these approaches is to improve liver function, overall survival, and life quality of patients, but only a few of these bioactive techniques have shown successful responses without initiating side effects.
