**8. Conclusion**

miRNAs play a pivotal role in liver cancer development; presumably in the early stages of HCC development, its multiple miRNA expression profiles may be distinguished depending on the etiological factor, such as HBV, HCV, NAFLD, or ALD. miRNAs are biomarkers with a huge potency as far as they are small, stable, and protected from RNases *via* protein binding or exosome membrane and their expression level change at the background of metabolism and signaling pathways modification during malignancy in the liver. Biogenesis of miRNA and its interaction with mRNA are not clear and involve different proteins and other noncoding miRNAs, which make it difficult to predict miRNAs expression level change in the specific cancer type and require special algorithm and big data sets. It should be noted that changes

in expression levels of almost all miRNAs listed above are not specific to liver cancer and are identified in prostate cancer, gastric cancer, colon cancer, and other cancer types. In this context, a multiple miRNA panel is a promising option for diagnostic purposes.
