**3. Finding better therapeutics**

The recently developed robotic resection offers the clinical advantage of a more precise incision than laparoscopy in the narrow space where the rectum is located and these precision technologies are constantly being improved [9]. The development of immunotherapeutic agents such as programmed death-ligand 1 antibodies, therapeutic chimeric antigen receptor-T cells, and cancer vaccines is also believed to be a remarkable achievement in taking one step closer to conquering colorectal cancer [10]. In addition, the development of sotorasib also means a breakthrough in the treatment of intractable cancer by mutation, recent clinical trials reported a disease control rate of about 73.8% targeting KRASG12C expressed colorectal cancer [11]. The case opens up the possibility that RAS mutations may no longer be defined as an area of an incurable disease. Along with these latest endeavors for the development of suitable therapies, several conditions that must be considered in order to develop better innovative therapies in the future or to overcome the limitations for the increase in therapeutic efficiency can be considered as follows: 1. Innovative diagnostic technologies such as proteomics, organoid culture, and virtual colonoscopy are encouraged to be included preferentially, and a developmental strategy reflecting characteristics of the target (eg. cancer stage, genetic predisposition, immune surveillance, and so on) is required. 2. Characteristics of the surrounding and internal microenvironment of the tumor, such as cancer-specific metabolism governing biochemical reaction by sphingolipids, characteristics of the tumor immune microenvironment, and the activity of microorganisms in the tumor, should be taken into account. 3. It would

*Introductory Chapter: Efforts to Conquer Colorectal Cancer from the Past to the Present DOI: http://dx.doi.org/10.5772/intechopen.106510*

be important to select essential nutrients in consideration of the patient's health condition and to find a strategy that can optimize their supply or control methods. Of course, these three categories for better colorectal cancer treatment are handled in this book with interest.
