**3. Conclusion**

In this chapter, we reviewed the mechanisms of action of fluvoxamine, including the serotonergic and the sigma-1 mediated mechanisms with regard to COVID-19 infection. Fluvoxamine is not FDA-approved for the treatment of any infectionrelated disorder. However, accumulated evidence highlighted potential beneficial effects.

To sum up, fluvoxamine could help to improve the clinical deterioration associated with COVID-19 symptoms. However, it is for future studies to mechanistically examine the potential mechanisms and profile consequences related to preventive measures of fluvoxamine in treating COVID-19 patients.
