**Abstract**

There have been over sixty microbiome scientific studies involving populations in Europe, Asia and America which have enabled researchers to be able to map the human microbiome. There have been also over hundred publications on the effects of skin cosmetic conditions on the dynamism of the human microbiome. The human body naturally has its own ecosystem of microbiome population which further studies have shown that they are associated and communicate with the human immune system. Recent studies have shown that there are benefits which are derived from a healthy microbiome which is composed of a balanced microbial diversity. Advances in technologies, and increased WHO guidelines due to the COVID-19 pandemic are increasingly being found to be impacting this long-standing human-microbiome synergy. The skin surface microbes and their interactions with other organisms have a significant capacity of influencing health by being immune modulators through either their cell components or other cellular metabolites. This Book Chapter shall discuss and propose microbiome targeted therapeutics strategy as a rationale to involve the role of immune system dynamics and human microbiome in the fight against COVID-19 pandemic and other pandemics.

**Keywords:** SARS CoV-2, WHO, sanitization, antibodies, vaccination, biota
