**6.3 Use of antibiotics during pregnancy**

Discoloration of the teeth is one of the dreaded complications of the use of Doxycycline in pregnancy, but the risk is not properly defined. Doxycycline is safe during breastfeeding [25]. Patients with glucose-6-phosphate dehydrogenase deficiency may have neonates who suffer neonatal jaundice/neonatal kernicterus due to sulfonamide use in pregnancy. And so, sulfonamides should be avoided in the third trimester and during breastfeeding [45]. Macrolide regimen (Erythromycin or Azithromycin) is the best suitable regimen of antibiotic treatment for pregnant and lactating women with granuloma inguinale. And so, pregnancy must be ruled out before the use of antibiotics in a sexually active woman of reproductive age. Again, this is not obtainable in most resource-limited settings due to a lack of trained personnel, ignorance, and poverty. In most developing countries, antibiotics can be bought over-the-counter, and sexually active women will usually go to the untrained personnel in the markets to procure antibiotics for treatment without prior doctors' prescription/evaluation.
