*4.3.3 Syphilis*

Darkfield examinations and molecular testes for detecting Tp are the definitive methods for early syphilis and congenital syphilis diagnosis. These tests can be done from material collected directly from the lesion exudate or tissue. Commercial NAATs are not available; nevertheless, some laboratories can provide developed and validated PCR tests.

For a presumptive diagnosis of Syphilis, two types of tests are required: A Non-treponemal test:

• VDRL (venereal disease research laboratory)

OR

• Rapid plasma reagin (RPR)
