**4.3 Treatment**

Gonorrhea treatment is complicated by the ability of *N. Gonorrhoeae* to develop resistance to antimicrobials. There is a high level of antimicrobial resistance in *N. Gonorrhoeae,* resulting in untreatable infections that in the future may become a significant major public health issue and pose the greatest challenges to the prevention and control of sexually transmitted infections [20].

Many of the previously recommended therapies are no longer effective, which makes treatment opportunities for *N. Gonorrhoeae* limited. Therefore, new dual antimicrobial treatment regimens are urgently needed [20, 28]. Zoliflodacin is the new recommended oral antibiotic that successfully treats most cases of uncomplicated gonorrhea [21].

