**1.6 Antimicrobial resistance mechanisms in** *N. gonorrhoeae*

*N. gonorrhoeae* is capable to damage its own genetic material because it is naturally competent for transformation during its life cycle and through different types of mutations [13]. This allows bacteria to survive and rapidly adapt to various environments (different sites in the human host). Gonococci develop all mechanisms of AMR to all antimicrobials used or recommended for treatment, e.g., (i) decreasing of the influx of antimicrobial and increasing of their efflux, (ii) modification of targets and reduction of affinity for antimicrobials, and (iii) enzymatic modification
