**5. Antimicrobial-resistant** *N. gonorrhoeae*

Gonorrhea treatment may be complicated by the ability of *N. gonorrhoeae* specious to develop resistance to antimicrobials drugs. Due to the emerging antimicrobial resistance dual therapy for gonorrhea with a cephalosporin plus either azithromycin or doxycycline, even if NAAT for C. trachomatis was negative at the time of treatment recommended by the center for disease control in 2010. Azithromycin might predispose to resistance due to its prolonged half-life [27].
