*Bacterial Sexually Transmitted Disease DOI: http://dx.doi.org/10.5772/intechopen.105747*

*T. pallidum* can infect the central nervous system at any stage of syphilis that result in neurosyphilis. Early neurologic clinical manifestations of syphilitic meningitis are usually present within the first few months of infection. Late neurologic manifestations occur 10 to >30 years after infection. Ocular syphilis and otosyphilis can occur at any stage of syphilis but are commonly identified during the early stages and can occur with or without central nervous system (CNS) involvement [2].
