Preface

Pyridine-based compounds play an important role in chemical and biological sciences. Proven as vital pharmacophores in drug design, they are currently part of numerous prescribed drugs to treat several critical human illnesses. The tremendous pharmacological activity and medicinal value of pyridine derivatives have attracted the attention of the scientific community.

This book presents recent developments in pyridine derivatives. It includes ten chapters in two sections on "Chemistry of Pyridine Derivatives" and "Applications of Pyridine Derivatives".

In the first section, Chapters 1 and 2 discuss the chemistry of pyridine derivatives and organic reactions of different categories. Chapter 3 describes a reaction involving pyridinium cations with copper halides in the formation of halocuprate complexes with diverse structural features.

In the second section, chapters examine the importance of pyridine-based compounds with documentation in notable fields of chemistry and biology. Applications are noted for both naturally available and synthetic analogues of pyridine compounds applied as drugs for treatment against a myriad of human diseases. Chapters 4–7 describe pyridine-based compounds applied against viral and bacterial infections, cancer, cardiac diseases, and other illnesses. Chapters 8–9 investigate the possibility of developing chemosensors based on pyridyl-based fluorophores and Schiff bases derived from formyl/amine-containing pyridine derivatives. An array of pyridine-functionalized fluorophores obtained from rhodamine, BODIPY, and 1,8-naphthalimide dyes have displayed excellent sensing capability towards various metal cations. Finally, Chapter 10 explores 2(4)-aminopyridines as chelators to platinum group metals such as iridium.

I am very thankful to all scientists who contributed their work to this book. I also wish to thank IntechOpen for giving me the opportunity to edit this volume.

> **Dr. Satyanarayan Pal** Associate Professor, Department of Chemistry, Utkal University, Bhubaneswar, India

**1**

Section 1

Chemistry of Pyridine

Derivatives

### Section 1
