**Abstract**

Cyber-physical systems (CPSs) are the intelligent systems that offer an interaction among computational, software, and networking resources in a continuous and dynamic fashion. Future systems are likely to be created and developed using CPSs, which have been recognized as a significant area of research. The electric power grid, energy systems, body area networks, modern vehicles, smart homes, cooperative robotics, and smart transportation are the examples for CPS. The security aspects of CPSs can be enhanced with blockchain (BC) technology. For instance, with the combination of CPSs and blockchain, a peer-to-peer energy market is made possible where machines may automatically buy and sell energy based on parameters specified by the user. In this chapter, we summarize recent developments in the creation and applications of CPS, the state-of-the-art and pertinent concepts, numerous CPS applications that have employed blockchain, relevant solutions, and open challenging issues.

**Keywords:** cyber-physical systems, blockchain, power grid, internet of things, transportation systems, vehicular systems
