**Abstract**

The chapter presents the urban and regional changes in the city of Ioannina, Greece. This city is located in the periphery of Epirus, which is in the western Balkans, Eastern Europe. The chapter examines, with the tools of aerial photos and QGIS software, the spatial transformation of Ioannina city from 1940 to 2015. Map science is a field through which the users could observe and compare maps from past to future. The plans and the planning were formed under the values, standards, and fundamentals of the mosaic of politics, good practices, urban rules, and citizen level. The urban space has already changed until nowadays. The chapter examines the reasons for urban politics and social–economic moments that became the epitome of these urban and regional changes. The results show the comparative spatial study from each historical period.

**Keywords:** analysis, cartography, urbanism, policies, Ioannina city
