**7.4 Assessment of potential genotoxicity**

Assessment of potential genotoxicity of the foods obtained from GM crops for human health safety assessment is important. Genotoxic studies include the assessment of genetic material at various stages of DNA, chromosomes etc. [43]. Accordance with the "Food Additive Risk Assessment Guidelines" of the Japan Food Safety Commission were assessed the genotoxicity of 30 food-flavoring chemicals in GM crops. Of the 30 food-flavoring chemicals, three yielded a positive result in both Ames and CA tests [44]. Another 11 chemicals yielded positive results in the CA test. However, none of the chemicals yielding positive *in vitro* test results yielded positive results in the *in vivo* tests. These findings indicate no genotoxicity concerns of the food-flavoring chemicals belonging to the above mentioned 18 chemical classes used in Japan unless there are other structural modifications.
