**Abstract**

*Trichinellosis* is a food-borne, zoonotic disease that causes infection by a nematode parasite belonging to the genus *Trichinella*. This is an important disease, and its causative agent is prevalent throughout the world (cosmopolitan). More clinical awareness of *trichinellosis* is required due to its many outbreaks, increase in the consumption of pork meat and its by-products. *Trichinellosis* is an epizootic in nature and its economic burden is associated with the prevention of this disease from the human food chain. This disease is transmitted from animals to humans through the consumption of raw or undercooked meat containing encapsulated muscle larvae of *Trichinella spiralis*. This paper demonstrates the direct effect of progesterone (P4) and mifepristone (RU486) on the progesterone receptors of *T. spiralis*. Also, studied the challenges in the preparation of DNA and recombinant protein vaccination to control trichinellosis. It is simply done this study at different life cycle developmental stages of *T. spiralis*. Vaccines development against *T. spiralis* infection is the new paradime shift from prevention of trichinellosis to fulfilling the food safety requirements.

**Keywords:** *Trichinella spiralis*, immune response, progesterone receptor, hormones, vaccine
