**8. Conclusions and future perspectives**

Throughout evolution, helminths have conveyed a wide variety of host species, emerging sophisticated links, also regulate channels with, and even control of, their hosts' immune systems. In host-parasite biology, there is the fast invention that several helminth species mediate cross-phylum interactions by releasing exosomes which leads to the importance of this pathway. Classification as helminths, how large the extracellular parasites, may be capable to "reach in" into the host cells intracellular mechanism, rebuilding the behavior through every possible way. The absorption of exosomes is not a receptor-dependent process; this is hard for the host to grow countermeasures to inhibit properties of exomes on parasites, whereas this would

be easier for the parasite for abusing the tracking exosome for operative interfering particles, from enzymes to small RNAs, proteins and other modifiers of gene expression. Additionally, these vesicles suggest vigorous machinery to the parasites, which might transport their "message" through extracellular spaces present in diverse nature and quite probably through cells and tissues.

More information from exosomes of helminths would lead towards balancing their effects, gaining our prevailing knowledge about immunomodulatory proteins and glycan. If we can produce antibody reactions towards components of the surface membrane, which are needed for cell entry, exosomes could be a good vaccine target. Additionally, new drug aims may appear from elaborating the paths needed for the biogenesis of exosome in helminths, and the cellular events of a host cell, which occurs after helminth exosome uptake. Hereafter, a new opening has unlocked on how helminths overthrow the immunity system and how they deal works by defeating the strategy of the helminth.
