**6. The clinical stage**

Translational research in biomedical sciences translates basic research and experimental discoveries into health taking the route from benchtop to bedside. This important field has gained substantial attention and investments in the last two decades [319]. *Translational Research on Chagas Disease: Focusing on Drug Combination and Repositioning DOI: http://dx.doi.org/10.5772/intechopen.104231*

**Figure 4.** *Design of the clinical trial for testing the BZ-DSF combination. Reproduced from Ref. [320] (with permission).*

In order to reach a proof of concept on the effectivity of the DSF-BZ combination in human infection, a partnership was established gathering different units of Fiocruz. The present study comprises a translational approach that began with experiments in vitro, on the bench and now reaches the clinical stage at the Evandro Chagas National Institute of Infectious Diseases-Fiocruz, coordinated by the team of the Clinical Research Laboratory of Chagas Disease, with assistance of the Clinical Research platform. Therefore, the phase I/II clinical trial was elaborated (**Figure 4**) and published recently [320].
