*5.1.5 Nitrofurantoin*

Reactive intermediates are formed from nitrofurantoin by the action of flavoproteins as a result of which the bacterial ribosomal proteins are inactivated. Resistance to nitrofurantoin till date is much lesser in comparison to the other drugs available, this is attributed to the fact that it acts on multiple targets in the bacterial cell. Resistance may develop due to gene mutations such as nsfA and nfsB genes [44].
