**Abstract**

*Salmonella* genus represents most common food borne pathogens isolated from food producing animals and is responsible for causing zoonotic infections in humans and other animal species, including birds. As a result, *Salmonella* diseases are among the most common problems for the humans, animals, and food industry around the world. Despite rising attention about other pathogens, *Salmonella* continues to be the most prominent cause of food borne disease worldwide. *Salmonella* can be transferred to humans at any point along the farm-to-fork chain, most commonly through infected animal-derived foods such as poultry and poultry related products (eggs), pork, fish, and so on. Some *Salmonella* serotypes have been confined to a single serovar and are known as "host-restricted" while the others have a wide host spectral range and are known as "host-adapted" serotypes. Globally *Salmonella* infection causes huge mortality and the infection plays a huge role in immune response by evolving multiple mechanism to subvert immunity to its own benefit. Numerous infectivity markers and determinants have indeed been reported to play essential role in *Salmonella* pathogenesis to colonize its host by invading and avoiding the host's intestinal shielding system.

**Keywords:** *Salmonella*, serovars, infection, pathogenesis
