*5.1.4 Trimethoprim-sulfamethoxazole*

It works by inhibiting the folate synthesis pathway thus inhibiting the DNA synthesis in the susceptible organism. Though widely used as a first-line therapy for uncomplicated cystitis, the use of trimethoprim-sulfamethoxazole has been stopped for empirical use because of its resistance. Over 20% of the UPEC isolates are resistant to trimethoprim-sulfamethoxazole. Resistance to the drug is mediated by

