**4. Lactobacilli in the pharmaceutical industry**

The use of *Lactobacilli* has frequently been associated with the prevention of disease. It has been revealed from the literature that the oral administration of large dosages of lactobacilli is an effective and nontoxic in patients having Crohn's disease, AIDS and various types of enteritis, and in premature babies, children or the senior adults, all of those are possibly at risk of lactobacillemia [114–120]. In some cases, enteral administration of *Lactobacillus* species may be favorable [121] in rats and humans [122]. *Lactobacilli* may also have positive effects in the oral cavity, inhibiting cariogenic *Candida* and *streptococci* species [123]. Tallying to these trials, efficient medicines containing viable *Lactobacilli* with no side effects have developed (**Table 4**).
