**2. Method**

This article is a narrative review study include IL-6 and RNA virology, clinical impact, diagnosis, and treatment. The search was conducted using five keywords "IL-6," "RNA Virus," "IL-6 inhibitors" in combination with "human" in PubMed, Scopus, and ScienceDirect among articles between 2000 and April 2022. We focused on publications post-year 2000, with emphasis on the past 10 years, but we did not exclude commonly referenced, relevant, and influential older publications. The clinical trial, case–control, review, and a meta-analysis study of 20 years; 2000–2022 articles, case series, cohort, and cross-sectional studies were reviewed. We also reviewed the references of each article to include further other studies or reports not identified by the search. We excluded articles considering the expert viewpoints and letters to the editor. We limit our search to English written articles and articles on human study.
