**5.2 Limiting factors of the treatment**

Each treatment has its pros and cons, and so this also has the same [41]. The limitations reported were very few, and the research is being done to have a deeper knowledge of this aspect [45]. The high intake of nutraceuticals can be toxic, which can cause side effects rather than improvising the condition [9]. There should be a proper balance between the protection of healthy and tumor cells called prophylaxis and inhibition of the growth of only cancer cells known as therapeutic doses [31]. When the concentration of antioxidants increases, the low concentrations of free radicals escalate [3]. The supplements which are derived from plants and herbs are observed to have a higher risk of pharmacokinetic interaction with agents of chemotherapy [92]. The synergic effect is by concentration, which decides whether it is beneficial or harmful. The mixture of antioxidants increases that effect in several phases and is more important than a single one [9]. A limiting factor is an aspect that lowers the possibility of achieving the best. Here, comes the most important aid to getting the treatment, which is the cost [28]. The amount we pay includes goods and services tax (GST), hospital amenities and services, and imported medicines [35]. The medicines are very expensive because only developed countries have the services and industry to manufacture their medicines and could afford these medicines to some extent. But a large proportion of the world starves for it [41]. The technology and pharma industries take up their roles, which builds up their money graphs. Medicines and treatment are costly due to technology and less accessible to most people. The elite classes of society could afford them easily [43]. The point is the world doesn't revolve around a small proportion. Many people use up all their savings, but very few can win the battle [28]. Supportive aids like antiemetics and other medications are already at higher rates. For instance, in the case of colorectal cancer, the use of cisplatin and fluorouracil types of drugs will increase the cost, and then the synthesis will increase it. Chemotherapy, diagnostics, and all add up to it [29].
