*4.1.9 New approaches for cancer therapy with mushroom bioactive compounds (vaccinotherapy)*

Vaccine preparations with preventive activities against liver and cervical cancer associated with hepatitis B and human papillomatosis infections have been developed in Belgium and USA [66]. Currently, there is no commercialized vaccine for the protection of existing tumors, metastases, or relapses [3, 19]. The addition of immunomodulating substances of natural and synthetic origin to vaccines has shown promising potential to sufficiently enhance their anticancer properties. Therefore,
