**8. Mushroom and chronic diseases**

The therapeutic qualities of mushrooms, as well as the existence of bioactive substances, are their most notable characteristics. Mushrooms' pharmacological qualities include immune boosting, homeostasis maintenance, biorhythm modulation, and, most critically, the treatment and prevention of a wide range of life-threatening diseases such as uncontrolled cell division, cerebral disorders, and cardiovascular disease Mushrooms offer, antifungal, antioxidant, immunomodulatory, anti-angiogenic, anticarcinogenic, antiviral, antibacterial, hepatoprotective, hypoglycemia, antidiabetic, anti-inflammatory and other therapeutic properties [85]. Some mushroom polysaccharides or complexes with protein to form polysaccharides-protein which can enhance the host's defense system, it enhances non-specific immune response, and anticancer action [86]. Mushrooms are high in natural antibiotics. The molecule responsible for the antimicrobial action has been identified as oxalic acid. Eating Tricholoma populinum resulted in the resolution of severe allergy symptoms in two patients, one with thromboangiitis obliterans and the other with urticarial [87].
