**4.4 Antidiabetic activity**

Diabetes is a serious metabolic disorder characterized by an abnormal increase in blood glucose. For this reason, several research studies have considered evaluating the possible effect of ginger and its main bioactive components in the reduction of blood glucose [82].

It has been shown that the administration of 6-gingerol stimulates the activity of glycogen synthase 1 and at the same time favors the translocation of the glucose transporter type 4 (GLUT-4) to the cell membrane, favoring insulin to allow glucose entry in skeletal muscles and subsequent storage as glycogen [83]. Ginger consumption seems to reduce our values of glycosylated hemoglobin (HbA1c), fasting plasma glucose, insulin, total cholesterol, and triglycerides in patients with type 2 diabetes mellitus [84].
