*Medicinal Mushroom of Potential Pharmaceutical Toxic Importance: Contribution… DOI: http://dx.doi.org/10.5772/intechopen.103845*

there were high doses and schemes of *L. edodes* polysaccharide fraction administration in combination with a vaccine based on autological glycopeptides of Ehrlich's carcinoma, Sarcoma 37, LLC, L1210, and B16 cell lines [66]. Such preparations were prepared to improve the cytolytic activity of lymphocytes, the metabolic activity of peritoneal macrophages, and the cytolytic activation of blood plasma serum in the presence of complement in intact animals and in sarcoma-bearing animals [3, 47]. The recent identification of an immunomodulating protein Ling Zhi-8 has been reported from mycelia of *G. lucidum* with stimulatory activity on dendritic cells [67]. Industrial amplification of recombinant protein Ling Zhi-8 has been elucidated using a well-developed patented yeast system.
