**Abstract**

Newcastle disease virus (NDV) is an inescapable and financially significant microbe, which actually keeps on tormenting the Indian poultry industry. The illness has a wide variety in seriousness going from asymptomatic to 100% mortality. The causal specialist, NDV, is a negative-sense single-stranded RNA virus. Transmission happens by exposure to fecal and different discharges from tainted birds, and through contact with contaminated feed, water, devices, and apparel. In this study expression of cytokine genes in avian cells is identified as a basic proposal for researchers to tackle new castle disease.

**Keywords:** New castle disease, avian cells, cytokine genes
