**1. Introduction**

The world population has been increasing continuously that is anticipated to reach about 9.7 billion by 2050 and predicted to be 11.2 billion by 2100 [1]. This will be an important factor for the directional determination in agricultural management, which impacted the human population, environment, and ecosystems. These challenges should be systematically managed by integrating with the environmentally friendly innovative technology of Agricultural 4.0. The pests and plant diseases management agents will be based on natural products or biopesticides are the great promise in controlling yield quality. However, this agricultural management with natural products could be taken continually in steps to boost the consumption in the global market, which will likely increase in the future for replacing and reducing the chemical pesticides use. Presently, plant essential oil (plant EO) derived biopesticides

are assessed and accepted in many countries through the public or specific regulation uses for assessing the active compounds and substances. The suitable extraction methods are supported to create the natural product, which are the important operations of determining the biological activities of plant EO.

Therefore, this chapter will describe the application of plant EOs for antiviral activities and insect-pest managements as well as discussing the relative innovative technologies such as automation, smart devices, smart sensors, artificial intelligence (AI), novel techniques and technologies, and the Internet of things (IoT). These will be applied under sustainable agricultural managements by Agriculture 4.0. These integrated operations in various innovative technologies will be made it possible to be quickly successful to increase the role of natural products in sustainable agricultural managements.
