**4.7 Forensic implication of lead poisoning**

Regulatory toxicology consists of collection, processing and evaluation of epidemiological and experimental toxicological data, that end up in a decision for protection of health against toxic substances [128]. Clinicians treating plumbism from gunshot must be aware of potential incompatibilities between drugs and lead [129]. Mathematical modelling is becoming increasingly relevant for drug development [130]. One in every five injuries caused by firearm is fatal [131]. Ballistic weapon can move with a velocity of 915 m/s, whereas bullet can move up to 610 m/s [132]. Hence there is need for anatomical mapping of the target organs. Neck injuries caused by bullet are described according to the anatomical zones (1–111). Zone I extends from clavicle to cricothyroid membrane, zone II from cricothyroid membrane to the mandibular angle and zone III from mandibular angle to base of the skull [133]. But advanced neurotrauma research can improve the quality of life of patients that suffer from traumatic brain injuries [134].
