**Acknowledgements**

This study has been partially funded by The Spanish Ministry of Economy, Industry and Competitiveness through the grants Ref.: RYC-2014-2016,536 (Ramon y Cajal Research Program) to JCJ-L; and Ministry of Health and Families, Andalusian government. Funding for I + D + i in biomedical research and health sciences in Andalusia, grant Ref.: PI-0450-2019.
