*Anticoagulants and Hypercoagulability DOI: http://dx.doi.org/10.5772/intechopen.103774*

#### **Figure 1.**

*Coagulation cascade and its interrelationship with the fibrinolytic system. Both extrinsic and intrinsic pathways of the coagulation cascade join to initiate the activation of FX of the common pathway. These unite to a fibrin clot, which is eventually degraded by plasmin in the fibrinolytic system.*

The u-PA is another plasminogen activator secreted by several cells, such as fibroblasts, epithelial cells and the placenta. The indigenous form of uPA is transformed into a twochain protein by plasmin or following stimulation by the contact factors, such as FXII, prekallikrein and high molecular weight kininogen (HMWK) (**Figure 1**) [10]. The uPA and t-PA convert plasminogen into plasmin through urokinase plasminogen activatorreceptor (uPA-R) and LDL-receptor related protein-1 (LRP-1) respectively [11].
