**5. Conclusions**

Over the years, patients with AF, the elderly, the very elderly, and the fragile increase the likelihood of thromboembolic diseases, as well as having bleeding with gastrointestinal predominance, after a stroke or after falls.

Since the appearance of DOACs, an optimal, versatile, and easy-to-use treatment has been found to maintain the thin balance between patients who most need to be prevented from SE and Stroke, and bleeding.

A reduction given by the drug group was obtained, an average of about 50% of HICs with a decrease in major bleeding, including GI.

The decision of the type of DOACs must be made to the measure of each patient and taking into account the precautions of a prior comprehensive assessment of the long-lived person.
