**6. Monitoring adverse effects**

Heparin-induced thrombocytopenia (HIT) is a serious complication of heparin anticoagulant therapy and can cause thrombocytopenia, venous or arterial thrombosis, skin lesions, and rarely a systemic reaction that can be serious and fatal. HIT may occur in any patient who is receiving heparin [24]. Three [24–26] CPGs of the seven (43%) included recommendation to minimize the incidence of HIT, monitor the development of HIT, and therapeutic options for thrombotic event related to HIT. The ACCP, 2012 [37] and ASH, 2018 [38] have supplementary material that included recommendations about HIT and were not included in this study.
