**4. Indication and strategy of pharmacological prophylaxis in orthopedic surgical patients**

ACCP, 2012 [27] classified hip arthroplasty, knee arthroplasty, and hip fracture surgery as major orthopedic surgery. ASH, 2019 [22] recommendations 1 to 8 for patients undergoing major surgery were not included (generic recommendations). ACP, 2011 [8] contained recommendations only for medical patients.
