V.Idrabiotaparinux sodium

Idrabiotaparinux sodium is another related family also injected subcutaneously once a week. It has a similar chemical structure and mode of action as fondaparinux but with a half-life of about 5–6 times longer than fondaparinux (fondaparinux's 17 hours to about 80 hours), indicating that the drug needs to be administered only once a week. The biotin attached to its structure allows its neutralisation with avidin, an egg-derived protein with low antigenicity [2].

#### VI.Inhibitors of FXa

Rivaroxaban, apixaban, edoxaban, betrixaban, apixaban and edoxaban are the common types of FXa inhibitors. They act by inhibiting the cleavage of prothrombin to thrombin through binding to FXa. They do not usually require constant monitoring [14].
