*5.1.4 Buccal film*

The buccal films are designed to deliver drugs to the mouth mucosa. This aim may be supplementary difficult to achieve than it appears, as increased mouth residence duration is far from the sole influencing factor. In the direction of circumventing inter and intra-individual inconsistency, the oral mucosa drug saturation ought to be taken into account, as well as one-way absorption. As a result, multilayer films have been coined as an innovative term for buccal films. The benefits of this medication delivery technology are substantial. Beyond patient acceptance, the oral cavity has many advantages for medication administration [15].

Because the buccal mucosa has a small surface area meant for application of the buccal delivery system, device dimensions and drug load are constrained. The real region for medication absorption is determined by the dosage form's size. For buccal distribution, a device with a surface area of 1–3 cm2 and a daily dosage of 25 mg or a lesser amount is preferable. Because meal ingestion and/or drinking may necessitate the removal of the delivery device, the maximum duration of buccal medication administration is roughly 4–6 hours. The more rapid turnover of the buccal mucosal epithelium (3–8 days) compared to the skin (30 days) may alter medication absorption by altering penetrability properties regularly [52].
