*5.1.6 Transmucosal film*

Oral transmucosal distribution, particularly buccal and sublingual delivery, has advanced well beyond the use of traditional dosage forms, with new techniques being developed regularly. These transmucosal drug delivery methods have several benefits above oral administration meant for systemic drug delivery, together with the ability to skip the first pass effect and avoid presystemic elimination inside the GI tract. The administration of medications to the oral cavity has gotten a lot of interest because of its high potential for patient compliance and unique physiological characteristics. The distribution of medications within the mouth mucosal cavity is divided into dual categories: local delivery and systemic administration by the buccal or sublingual mucosa. Another key physiological obstacle to oral transmucosal drug administration is drug permeability through the mouth (e.g. buccal/sublingual) mucosa. The thickness of the oral mucosa, as well as the makeup of the epithelium, varies depending on the location [55].
