**3.6 Cancer treatment using a polymer drug combination**

The medications as well as the polymer have a physiologically labile connection. Paclitaxel [poly(L-glutamic acid)] is a chemotherapeutic medication employed to treat cancers of the ovary, breast, as well as lung. Phase III studies have been conducted on it. Among its 2'hydroxyl unit and the carboxylic acid of poly(L-glutamic acid), it possesses an ester bond [83]. To improve its efficacy as an antitumor targeted drug delivery, Poly (amidoamine) and PEG is covalently attached with the chemotherapy medication Paclitaxel. Both improve the solubility of the substance. In an in vitro investigation of mankind ovarian cancer cells, it was discovered that PEG-based conjugates lowered paclitaxel activity by 25-fold, but the Poly (amidoamine)]-G4 dendrimer increased its efficacy by more than ten times [12]. The medication 5-fluorouracil induces cell death. Some researchers created PLA nanospheres as an encapsulating reagent for 5-fluorouracil [12].
