**Abstract**

Polymers have helped to develop drug carrier technologies by allowing for the regulated release of bioactive molecules in consistent dosages over extended periods of time, cyclic dosing, and adjustable delivery of both hydrophobic and hydrophilic medicines. Formulations are released in a coordinated and consistent fashion over long periods of time. Polymers going to act as just an inert carrier whereby a substance can be conjugated having significant advantages. For instance, the polymer enhances the pharmacodynamic and pharmacokinetic characteristics of biopharmaceuticals in a variety of ways, such as plasma half-life, reduces immunogenicity, increases biopharmaceutical consistency, enhances the solubilization of low-molecular-weight substances, and has the prospects for targeted delivery. Smart polymeric delivery systems, in instance, have been investigated as "smart" delivery methods capable of releasing encapsulated pharmaceuticals at the right time and place of activity with respect to certain physiological stimuli. The development of novel polymeric materials and cross-linkers that are more biocompatible and biodegradable would expand and improve present uses. Polymer sensitivity to a particular stimulus may be tuned within a limited range because of the diversity of polymer substrates and their sequential production. The methods through which polymer frameworks are formed *in situ* to construct implanted systems for continuous release of medicinal macromolecules are discussed in this chapter, as well as numerous applicability of enhanced drug delivery.

**Keywords:** polymeric material, drug delivery, thermally responsive, smart polymer, glucose, enzyme, oxidation-reduction
