**3. Synthesis of NMOFs**

Specialized synthetic routes are a prerequisite to obtaining MOFs in the nanorange, ideal for drug administration. The choice of synthesis protocol determines the final size, crystallinity, morphology, uniformity and stability of NMOF. **Figure 2** shows a summary of the most often used approaches.


**Figure 2.**

*Schematic representation of various synthetic methods used for the synthesis of NMOFs.*

Other, less commonly used methods include the use of microwaves, ultrasounds, etc. [21, 22]. NMOFs are generally post-synthetically modified or altered to impart them with extra stability, targeting ability, and biocompatibility [23].
