**2.3 Polymers sensitive to two impulses (pH and temperature)**

These really are polymeric frameworks that are thermal and pH-sensitive, but they are created by combining ionizable with lipophilic (inverse thermosensitive) moiety in a straightforward way [42]. Chitosan, acrylic acid, N,Ndime thylaminoethylmethacrylate, and other polymers that really are thermal and pHresponsive are instances. This is accomplished mostly by copolymerizing monomers with all these molecules, integrating thermally responsive polymers with polyelectrolytes, or developing novel monomers that adapt to both stimulation concurrently [43, 44].
