*2.3.1 Compounds acting via TRPV Channels*

• Afidopyropens

Afidopyropens (for example the keto-pyripyropene A) are new hemisynthetic insecticides derived from pyripyropene A (**Figure 8**). This family of molecules presents a strong insecticidal activity against aphids. These molecules modulate TRPV channels in the chordotonal organs of insects [46]. It is a class of ester molecules that are marketed under the common name of afidopyropen [47] including ketopyripyropene A. The biomimetic hemisynthesis of keto-pyripyropene A is done as

#### **Figure 7.**

*Structure of a TRPV1 subunit. A. N-terminus containing 6 ankyrin subunits (A1–A6) and a linking region consisting of a linker and a pre-S1 helix segment. B. Transmembrane region with 6 helical segments (S1–S6). C. C-terminus containing a TRP domain and binding sites for protein kinase A, C, phosphatidylinositol-4,5 bisphosphate (PIP2), and calmodulin [43].*

**Figure 8.** *Keto-pyripyropene A synthesis [45].*

#### *DOI: http://dx.doi.org/10.5772/intechopen.105158 Biomimetic and Hemisynthetic Pesticides*

follows, a modification of pyripyropene A through a Jones oxidation allows to obtain keto-pyripyropene A (**Figure 8**) [45].
