**5.5 Plant MIR167e-5p suppresses intestinal cell proliferation**

A recent study has found plant-derived MIR167e-5p to regulate enterocyte proliferation in vitro in cancer cell lines. Plant MIR167e-5p decreased cell proliferation following treatment with 20 pmol of MIR167e-5p over a 72 h period. The tests included viability assays determined by MTT at different times. In this study, a bioinformatic program was employed to identify plant miRNA targets due to their involvement in auxin response factor processes in plants, resulting in a conserved putative site in β-catenin gene in human, key in the Wnt/ β-catenin pathway related to cell proliferation, differentiation, and maintenance. Demonstrating that the plant MIR167e-5p could decrease protein levels and inhibit cell proliferation [40].
