**6.1 Anti-parkinsonism activity**

Parkinson disease is arising due to the degradation of dopamine- carrying neurons in the substantia nigra. The neuronal death occurs in PD is due to the damage of free radicals and lewy's bodies formation [40]. Levodopa is used as the first line drug for the treatment of Parkinson disease [41]. Powder of the whole plant of *A. aspera* is extracted by using hydro-alcoholic solvent and its get evaporated to a concentrate by rotary evaporator at 40°C [42]. 24 rats were divided into four groups (*n* = 6). Hydroalcoholic extract at a dose of 200 and 400 mg/kg was administered to the rats before 30 minutes of haloperidol treatment for 20 days. In a study of anti-parkinsonism activity, the ant-parkinsonism effect of hydro alcoholic extract of *A. aspera* on haloperidol which is administered at a dose of 2 mg/kg via intraperitoneal route induced catatonia in rats. In haloperidol treated rats the motor coordination was studied by using rotarod test and hang test. The increase degree of catalepsy in haloperidol treated group was measured after 60 and 90 minutes of administration. The result has shown score of catalepsy was significantly decreased after 60 minutes with the test drug HA at a dose of 200 and 400 mg/kg. It is also demonstrated that group exhibited maximum reduction in the catalepsy, which is treated with 400 mg/kg. The results of rotarod test show that the retention time was reduced in the haloperidol treated group. The retention time significantly improved in HA treated group. Among these groups, maximum retention time was noted in the 400 mg/kg treated group [43].
