**4.** *Annona muricata* **as an antiviral agent for the management of SARS-CoV-2?**

According to WHO, the current management of COVID 19 at home of patients or confirmed cases consists mainly of antipyretics for fever and headache, as well as good diet and hydration [27].

Cameroon is among the highest species diversity in Africa, yet herbal medicines is not yet completely acknowledged by the country's healthcare system, and herbal drug development is limited despite numerous ethnopharmacological surveys on various African plant species.

According to Matshidiso Moeti, the WHO regional director for Africa, interest in African traditional medicine is growing as a potential treatment for COVID 19 [28].

Malagasy is the only African country to already have succeeded in producing a potential cure for COVID 19.

Madagascar is the only African country to have previously succeeded in developing a COVID 19 treatment.

Researchers from Madagascar's Malagasy Institute for Applied Research recently developed COVID Organics, a novel coronavirus antidote (IMRA). According to the country's president, Rajoelina, it has anti-coronavirus potential [29].

There was no specific antiviral agent or vaccine ready for healthy people at the beginning of the epidemic.

Nowadays, there are many antiviral agents for the treatment of COVID 19 including such hydroxychloroquine (HCQ ), chloroquine (CQ ), and ivermectine (IVM) that are not yet approved by the FDA and are not recommended for use in the treatment of COVID 19 [30].

Graviola's bioactive compounds give it a potential antiviral agent, however it's not optimal.
