**5.10 Antiproliferative effects of rose hip**

The involvement of ROS and free radicals in the pathogenesis of certain human diseases also including aging and cancer is increasingly recognized [117], and there are an increasing number of papers in which *Rosa canina* L has been tested on different cell lines in the laboratory. Such studies include colon, lung, and prostate cell lines in which cell proliferation and apoptosis have been reported [118, 119]. However, we were not able to find any clinical studies performed in humans that specifically focus on the impact of any rose hip species including *Rosa canina* on the survival rate among humans suffering from cancer. And as we do not want to create false hopes in people experiencing such a serious disease, our statement is: That from the present knowledge and insight it is too early to discuss the possible impact rose hip treatment might have on proliferative disorders in humans.
