**6.8 Anti-inflammatory activity**

The leaves of *A. aspera*are used for the treatment of dermatoligical disorder [53]. It was investigated that alcoholic extract of *A. aspera*has potential anti-inflammatory effect in Wistar rats at different doses such as 50, 100 and 200 mg/kg. Anti-inflammatory effect of *A. aspera* extract carried out by using carrageenan-induced paw edema (acute inflammatory model) and cotton pellet granuloma test (chronic inflammatory model). All the doses of alcoholic extract of *A. aspera* tested in carrageenan-induced paw edema caused a significant (*p* < 0.05) and decreased paw edema 32–40.5 compared to control group. In cotton pellet granuloma model, the concentration of *A. aspera* (50, 100 and 200 mg/kg) caused a significant (*p* < 0.05) and marked inhibition 34.6% of granuloma weight as compared to control group [54].

*Comparative Study between Herbal and Synthetic Antidepressant Drugs DOI: http://dx.doi.org/10.5772/intechopen.103977*

## **6.9 Antipyretic activity**

In a study of anti-pyretic activity of crude extract of *A. aspera* was carried out by brewer's yeast-induced pyrexia in rats. Initially rectal temperatures were recorded. Administration of the yeast at a dose 10 mg/kg to the rats produced significant increase in rectal temperature 24 hours after yeast injection [55]. The methanolic extract of leaves of *A. aspera* consist of alkaloids, steroids, proteins, flavonoids, saponins, mucilage, carbohydrates and tannins. The methanolic extract was administered orally to different groups at a dose of 100 and 200 mg/kg by intra-peritoneal route. 0.3 ml of normal saline was administered to the control group. Paracetamol (150 mg/kg) used as a standard drug. The methanolic extract of *A. aspera* demonstrated significant (*p* < 0.01) antipyretic activity. The dose at a 200 mg/kg extract has shown a good antipyretic activity (*p* < 0.01) with all the doses used when compared to the control group [15].

### **6.10 Anthelmintic activity**

Helminthiasis is one of the most popular disease and one of the most serious diseases [56]. Stem powder of *A. aspera* extracted with methanol and water. It was extracted by using maceration process. Its chemical constituents such as saponins A, saponins B, terpenoids and volatile oils showed anthelmintic activity. Albendazole used as a standard drug for the comparison of anthelmintic activity of *A. aspera.* Extract of it's used at different concentration (2.5, 5, 10 and 20 mg/ml) for testing anthelmintic activity which based on the determination of time of paralysis and time of death of the worms. All the methanolic extracts of *A. aspera* showed the better protection against the helminthiasis [57].
