**5.1 Anti-cancer activity**

Across the globe different forms of cancer is the most fatal disease. Many types of medicines are available in the market for the treatment of cancer but the number of successful and safe drug is very few. Anthocyanins extracted from the *M. alba* fruit shows an invasion in human lung metastatic A549 carcinoma cells. Flavonoids isolated from the leaves of this plant acts as a cancer inhibiting profile agent [22]. From root bark of mulberry Albanol A (Mulberrofuran G) can be extracted which induce potent cytotoxicity in HL60 (Human Leucamia Cell line) by inhibiting topoisomerase II activity [14, 39]. *M. alba* leaf extract shows anti- proliferative lectin induced cell death by apoptosis in human breast cancer (MCF-7) and colon cancer (HCT-15) by inducing DNA fragmentation and morphological changes. Flavanone glycosides present in the root bark of *M. alba* having anti-proliferation activity against human ovarian cancer in H0-8910 cells [2].
