**2.7** *Hypoxis hemerocallidea*

*Hypoxis hemerocallidea* (**Figure 8**), also known as African Potato, belongs to the *Hypoxidaceae* family [35, 36, 59]. It is called inkomfe in Zulu and Lotsane in Tswana [60]. *Hypoxis hemerocallidea* is widely distributed in Southern Africa including, South Africa, Lesotho, Mozambique, and Zimbabwe and is also found in East Africa [36]. It is used traditionally to treat HIV/acquired immunodeficiency syndrome, arthritis, diabetes mellitus, testicular tumors, cancers, infertility, urinary infection, cardiovascular diseases, and respiratory disease such as tuberculosis (**Table 1**) [35, 36]. *Hypoxis hemerocallidea* contain phytochemicals, such as sterols, sterolins, norlignan, daucosterol, and rooperol, responsible for its therapeutic benefits [35]. Hypoxide is the main glycoside isolated from *Hypoxis* species [36]. Molecular docking analysis identified hypoxide (**Table 2**) as a potent inhibitor of SARS-CoV-2 receptor-binding domain with the docking score of −6.9 kcal/mol [19]. The study conducted on rats has demonstrated that *Hypoxis hemerocallidea* has the ability to impair kidney function. There is a need for more *in vitro* and *in vivo* research on the toxicity, safety, and efficacy of *Hypoxis hemerocallidea* [61].
