**3.3 Dosing**

Like any treatment, RRT intensity or delivered dose must be tailored to the patient's need. While underdosing may result in insufficient clearance of uremic toxins, uncontrolled electrolytes, or acid–base status, overdosing leads to electrolytes disorders, hydrophilic micronutrients depletion, hazardous therapeutics dosing (e.g., antibiotics), and unnecessary expenses [29]. Ultrafiltration is a critical component of RRT prescribing but is not part of *dosing* which refers to the clearance capability. Another key point is that the actual delivered dose is often lower than the prescribed dose for multiple reasons: vascular access limiting Qb, interruptions for radiologic studies or surgery, circuit change or clotting, etc.
