*3.3.1 Intermittent modalities*

For all intermittent modalities, as seen in **Table 7**, the blood flow rate is the limiting factor highlighting the value of maximizing the potency of vascular access. A subsequent option to optimize clearance is increasing the *frequency* or *duration* of treatments. Then, to lesser levels, increasing filter surface and dialysate flow rate<sup>3</sup> . For dosing assessment (or *clearance adequacy*), guidelines recommend using the clearance

<sup>3</sup> A Qd/Qb ratio higher than 1.5 has minimal to no impact on small solute clearance while using high-flux filter


*Qb: blood flow rate, Qd: dialysis flow rate, UFH: unfractionated heparin, LMWH: Low-molecular-weight heparin. \*See anticoagulation section for more details.*
