Preface

Sickle cell anemia is a preventable yet prevalent inherited blood disorder. It arises due to the inheritance of two abnormal sickle cell genes (SS), one from each parent. The disease is a common cause of mortality and morbidity, particularly in low-income developing countries. The vaso-occlusive crisis is the most common presentation and the leading cause of death in patients with the disease. Its pathophysiology involves the obstruction of blood flow to vital organs by the sickled red cells resulting in ischemia, necrosis, and pain. This book presents evidence-based best practices in the diagnosis and clinical, psychosocial, and pharmacological management of sickle cell disease patients. It contains cutting-edge and evidence-based information and is highly recommended for all healthcare professionals responsible for managing patients with sickle cell disease. There is no doubt that this book will improve the quality of care offered to patients across the globe.

> **Osaro Erhabor** Professor, Usmanu Danfodiyo University, Sokoto, Nigeria

**1**

Section 1

Complications and

Management of Sickle Cell

Disease

Section 1
