**2. Early uses and challenges of neonatal OCT**

Adoption of OCT into neonatal population has been limited due to various reasons such as absence of available equipment for quick and accurate imaging without sedation [9]. Early attempts to use OCT in neonatal population were made in operating room under general anesthesia [10, 11]. Vinekar et al. were among the first to use handheld OCT in premature infants. Using the handheld device that was made from a tabletop spectral domain OCT scanner they showed clinically undetected abnormal findings of cystoid spaces and greater foveal thickness in patients with stage 2 ROP. Also, they demonstrated the possibility of OCT imaging of unanesthetized infants at bedside [12].
