*5.7.3 Neuropillin-1 (Nrp1)*

NRP1 is an essential component of Neurolippin-1/Semaphorin 3A signaling pathway. This pathway is responsible for the proper development of vascular and neuronal structures in inner ear as well as hair cell organization [175, 176]. A GWAS study on mice showed progressive hearing loss with age and abnormalities in inner ear microvasculature [177]. Although these investigations suggest that *Nrp1* can be associated with ARHL in mice, no such studies have been performed in humans.
