**Table 3.**

*Main reported vectors of neglected arboviruses in Latin America.*

A significant problem in the diagnosis of these arboviruses includes the clinical and epidemiological overlapping [4], even with possible coinfections [16, 22, 98], but also the problems derived from potential antibody cross-reactivity that may yield serological false-positive results, now even, including coinfections and cross-reactivity with SARS-CoV-2 [18, 99–102]. Then, molecular diagnosis of them is critical, including multiplex testing to search simultaneously many arboviruses and perform more specific serological testing, using better antigens, such as plaque reduction neutralizing antibody testing (PRNT) [103], especially in patients with risks for severe or complicated disease.

For the control of these neglected arboviruses, vector control is key, especially on *Aedes* and *Culex* species that represent the main mosquito genuses related to their transmission (**Table 3**).

As expected, no vaccines nor antivirals have been developed for these neglected arboviruses [104–106], although there is hope for them in the future. Therefore, symptomatic treatment is indicated with them after establishing a specific and confirmed molecular diagnosis.
