**5.2 B-cells**

B cells is a component of the white blood cells and humoral immunity [66]. B lymphocytes secrete antibodies which are critical in pathogen specific recognition and elimination [66]. These cells are essential in the production of antigen-specific immunoglobulin (Ig) which are the agents that binds to pathogens [66]. Major sites of B cells in human include the blood and the lymph nodes [66]. Spleen and tonsil are other areas B cell are be found [66]. B cells and T cells work in concert to eliminate pathogens from the body [66]. After production and maturation in the bone marrow, B cells circulate through the blood and lymphoid system. Upon encounter with a specific pathogen, binding occurs. Subsequent assistance from the T cells lead to the elimination of the invading cell from the host [66].
