**2. Materials and methods**

All the chemicals were sourced from Sigma Aldrich, Bengaluru, and used for the complete experimental work. The stock solutions were prepared freshly every time using Milli-Q water before conducting any experiments, to avoid data inconsistency.

Conductivity meter (Eutech, CyberScan CON 510, supplied by ComBiotech, Bengaluru) was used to analyze the concentration of sodium hydroxide solution. The customized reactors were built using materials sourced from ComBiotech-Bengaluru, Huber-Germany, and Swagelok-India respectively. We have investigated the saponification reaction as a general procedure for the process intensification in these customized flow reactors.
