**6. Conclusions**

Taken together, F elements causing many illness by producing oxidative stressmediated toxicity in different organs. However, the natural antioxidant from plant sources has rich chelating ability than synthetic chelators for many uncurable diseases. The supplementation of natural antioxidants mentioned in this book chapter could mitigate all kinds of organ toxicity elicited by F via modulation of oxidative damage, apoptosis in both in-vitro and in-vivo studies on different animals. This exploration also shed the lights on natural antioxidant therapy and future research in this fields.
