**Abstract**

The objective of this work was to develop a systematic strategy for generating efficient, alternate reaction paths that could be used to manufacture the top 100 industrial chemicals, currently produced from crude oil, using renewable feedstocks. Manufacturing these chemicals from oil, coal, or natural gas results in increasing carbon dioxide levels in the atmosphere, responsible for global climate change. The methodology employed here uses the existing knowledge on the conversion of carbonneutral feedstocks, such as biomass, wood, etc., to suitable precursor raw materials. Known industrial reaction paths, currently used for manufacturing the top 100 industrial organic chemicals, are then combined with the known conversion of carbon-neutral feedstocks to systematically develop and evaluate alternate carbonefficient reaction paths. The fractional carbon economy was determined from a comprehensive listing of industrial reactions paths, which also gives the yields and efficiencies of these industrial reaction paths, currently being practiced in the chemical industry. Reaction pathways with maximum carbon economy for manufacturing the top 100 industrial chemicals from carbon-neutral feedstocks have been presented in this chapter.

**Keywords:** reactions, carbon, economy, carbon-neutral, industrial chemicals
