**Abstract**

The chapter will briefly present three distinctive concepts of the micropump actuator driving module, each with its waveform specifics and their impact on particular micropump performance (pumping media, flow rate and backpressure). First presented concept is based on two mutually-exclusive boost switched-mode power supply modules. Characterization of this module identified output voltage asymmetry to be the limiting factor of micropump performance. To assure driving symmetry, an alternative driving module, based on independent high-voltage stages and optocouplers, was implemented. This design is capable of driving a piezoelectric micropump with a rectangular waveform of programmable frequency, positive and negative amplitudes, slew rates and dead time. While this design provides maximum flow and backpressure characteristics, it does not offer minimal current consumption and long-term operation. To overcome this difficulty, our current design is based on an embedded arbitrary waveform generator, which offers an efficient trade-off between high pumping performance and low current consumption.

**Keywords:** piezoelectric micropumps, mutually exclusive switched-mode power supply modules, optocoupler, arbitrary waveform generator, low current consumption
