**6. Conclusion**

This chapter reported on the structural and optical properties of ZnO-SPR with different layer structures (single, IMI, and hybrid samples) from experimental and theoretical approaches. First, the SPR properties and sensing performance of the single sample were investigated. Second, the IMI sample was introduced in ZnO-SPR devices to enhance sensing activity. Finally, the hybrid sample with the capping of thin dielectric layers to ZnO-SPR was developed to monitor biological interactions between biotin and streptavidin. This work highlights new insights for fabricating biological sensing platforms on ZnO materials.

*Biological Sensing Using Infrared SPR Devices Based on ZnO DOI: http://dx.doi.org/10.5772/intechopen.104562*
