**5. Conclusion and future perspectives**

The application of biosensing in tissue engineering, regenerative medicine, and mHealth has been fast growing. However, the growth has been limited even though some sensors including piezoelectric sensors have been described in previous research works and are already present in the market depicting high sensitivity and sensibility. The popularly known and successful ones among all are the electrochemical and mHealth, whereas some others cannot be used practically.

In tissue engineering and regenerative medicine, real-time monitoring of analytes is still at its early stage, and further research can bring enormous possibilities in the field. Future studies should focus on overcoming the challenges of miniaturization and integration of biosensors in microfluidic systems. Microfluidic technology with automated, sensitive, and real-time monitoring capabilities will play significant roles in translating to clinics. The use of microfluidic technology and many other mentioned technologies (methods) for global biosensing applications will need the utmost high standard of the systems and the whole process.

Incorporating biofabrication techniques into biosensing fields is important. For multiplexing signals and evaluating cellular responses in 2D and 3D, high-quality transducers could be used to separate and quantify analytes of interest. Future studies *Recent Advances in Biosensing in Tissue Engineering and Regenerative Medicine DOI: http://dx.doi.org/10.5772/intechopen.104922*

could be carried out by joining the recent biofabrication techniques (contact-based and noncontact-based), to yield better advances in biosensing technology, more particularly, in advanced extrusion-based bioprinting (noncontact-based printing method), to print living biosensing structures (as implantable therapeutics) with the use of coaxial and triaxial nozzles for various healthcare-related issues. The synergy of biofabrication and sensing will generate the next generation of biosensors possessing a high degree of sensitivity, throughput, and dynamic range in one sensor. In the end, the synergetic effect will yield a great impact on future sensing, monitoring of diseases, research, diagnostics, and therapeutic applications.
