*Mesenchymal Stem/Stromal Cells and Hydrogel Scaffolds for Tissue Engineering DOI: http://dx.doi.org/10.5772/intechopen.101793*

released extracellular vesicles (EVs) reveal substantial therapeutic effect in numerous pathophysiological conditions and potentially reconstructing an extensive range of diseased or damaged tissues and organs in tissue regeneration engineering, which have been predominantly demonstrated from pre-clinical or clinical *in vitro* and *in vivo* studies. MSC-encapsulated hydrogel scaffolds demonstrate enhanced cell vitality and committed differentiation, prolonged fundamental and operational consistency, which thus hold promising prospects for tissue engineering and the resultant regenerative medicine. Meanwhile, the exosomes and other nano-scale secretions released from the multivesicular MSCs encapsulated into appropriative hydrogel formulations (e.g., HA, nHAP, PLGA, pDA, and FHE) have manifested higher therapeutic potential in both fundamental research and clinical application. Overall, the current progress of regenerative medicine will extensively benefit from the "advantaged" artificial hydrogel/MSC-based cytotherapy in the near future.
