**4. Drug repurposing in coronavirus**

CoVs are RNA-viruses responsible for GIT respiratory and neurological disease in animals and zoonotic infection in humans, it has the potential to cross-species to species transmission in the domesticated animal which will become the source of spread in human. The major concern of outbreak is the morbidity and mortality of infection in human, and animal adaptability according to the physiological system and ability to upgrade itself to suppress the immune system which make life decline.

SARS-CoV is highly pathogenic it emerged in China in 2002/2003 with 8098 infections and 10% mortality, on the other hand in 2012 MERS-CoV outbreak spread to 27 countries so far by 35% mortality rate, to manage the threat of both the outbreaks by adopting three independent studies reporting an approach by DR for anti-CoV drug discovery were published, this methodology tested against MERSand SARS-CoV, came up with the screening of dopamine receptor antagonist and antimalarials [6].

**Drugs:**


*Reprofiling of Octogenarian Antiviral Agent: A New Avenue Venture to Discover Viral Infection DOI: http://dx.doi.org/10.5772/intechopen.102825*

#### **4.1 Drug repurposing in influenza and dengue**

Influenza is an air-borne disease, belong to the family Orthomyxoviride and it causes a major pandemic outbreak. DR camping identified FDA-approved drugs which are under clinical evaluation with anti-influenza activity [7].

Drugs:


whereas Dengue virus (DENV) is a mosquito-borne disease, currently it is rapidly spreading important arthropod-born viral disease in the world. It requires the new drug to target the host cells, whereas the repurposing approach was found to be effective for therapeutic intervention.

Drugs:

