**3. Psoriasis/psoriatic disease**

Psoriasis is a progressive self-sustained and self-perpetuated inflammatory disease driven by the coexisting autoimmune and autoinflammatory pathways that, while primarily presenting with cutaneous involvement, also manifests as seronegative inflammatory arthritis with synovitis, enthesitis, dactylitis, and spondylitis [19]. It is quite heterogeneous in nature, characterized by a dynamic interplay of the individual's genetic landscape, tissue-specific immune micro-environments, metabolite/ immune-metabolite signature, host-microbiome interactions, and biomechanical stressors [20, 21].
