*4.2.2 Citric acid cycle/Krebs cycle*

Kreb's cycle serves as an important node for multiple nutrient inputs as it integrates fatty acid (FA) and AA metabolism with that of glucose by generating a variety of metabolic biosynthetic intermediates required for FA and AA synthesis and by metabolizing other substrates such as glutamine via glutaminolysis or FAs via β-oxidation. Kreb's cycle results in the generation of different epigeneticregulating metabolites, e.g., α-KG, 2-HG and acetyl-CoA to calibrate T-cell function [42].

*Th17/IL-17, Immunometabolism and Psoriatic Disease: A Pathological Trifecta DOI: http://dx.doi.org/10.5772/intechopen.102633*
