**6. Adipose tissue and systemic immunometabolism**

One tissue that has recently become an area of intense metabolic research is adipose tissue. The adipose tissue is an important metabolic organ that regulates the balance of energy intake and consumption and is actively involved in the regulation of many systemic metabolic pathways including glucose and lipids. Adipose tissue also serves as an endocrine organ (secreting bioactive adipocytokines) and an important immune cell niche (secreting chemokines and cytokines, exerting beneficial or detrimental effects on immunometabolism) with visceral white adipose tissue as the major immune-metabolic communication hub. Adipose tissue also

### *Th17/IL-17, Immunometabolism and Psoriatic Disease: A Pathological Trifecta DOI: http://dx.doi.org/10.5772/intechopen.102633*

communicates with other organs including the liver and muscle and contributes to systemic metabolism *via* secretion of a variety of bioactive molecules as mentioned above [70]. Adipose tissue (visceral as well as cutaneous) has recently emerged as an important node linking immunity/inflammation, obesity and a cluster of metabolic diseases including psoriasis. Adipose tissue is a highly dynamic tissue showing the extreme degree of plasticity and remodeling potential (by expansion or contraction of adipocytes in response to energy surplus or famine) that makes it a suitable centre for maintaining immune-metabolic homeostasis [71].
