**5. Conclusion**

Ps management is constantly evolving in parallel with new insights in the immune pathogenesis. In spite of extensive studies, Ps remains a complex and enigmatic disease as still, its clear etiology is a matter of intense research. New drugs that are targeting the immune pathways using biologics and small molecules have significantly improved life quality in Ps. Biomarkers from the area of cytokines, various soluble mediators, cell-surface molecules or receptors, intracellular signaling pathways molecules, encompass the panel of tools that can improve diagnosis and prognosis in Ps. The most recent image of Ps within the immunological system highlights the importance of immune cells involved in Ps.
